Successfully treated carcinoma erysipeloides from gastric cancer.

Normal salivary gland tissue has been recognized to positively stain for PSA, independently of gender, while immunostaining for AR has not been consistently found [6, 7]. Immunostaining for AR, and occasionally for prostatic acid phosphatase and PSA, has been reported in duct carcinoma and adenocarcinoma of salivary glands in both sexes [3–6, 8]. These findings suggest that, unlike prostate cancer, PSA expression could be independent of androgen stimulation in normal salivary gland tissue. However, the biological significance of PSA and AR expression in normal tissue and in SGCs, respectively, remains unknown. In prostatic cancer, androgens play a role as both a survival and growth factor and androgen-deprivation therapy is successfully used. Our experience suggests that a similar mechanism may be implicated in AR-positive salivary gland tumors. Studies looking at the underlying biological role of AR expression in SGCs are warranted. This work was supported in part by AIRC (Associazione Italiana per la Ricerca sul Cancro).